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, Noukakis TG (1998) The effect of acid on the solubility and dissolution rate. Pharm Res 15(12):1652-60 Ayers JE, Tonge PJ, D’Souza KJ (1992) Effect of buffers on calcium phosphate dissolution rates in 0.14M HCl at 37oC: Buffer effects are due to their ability either to bind protons or react with them as well as by buffering pH changes. Arch Biochem Biophys 296(18):626-33 Berg S, Jensen ASL (1962). Solubility product constants for calcium phosphates in relation to buffer capacity. Biochimica et biophysica acta 55:283–, Castles DL, Gettner RC (1970). Studies on the solubility of calcium phosphate in acid solutions. Biochemistry
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Norton HL Jr et al., eds. “TransactionsThe addition of acid to a solution containing calcium phosphate will increase the solubility of the calcium phosphate. This is because as pH decreases, the dissolution rate increases and so does solubility. Another reason for this is that when an acid ionizes it becomes negatively charged which attracts positively charged ions in the solution. When these two charges collide they become neutralized and free to dissolve into each other more easily, thus increasing solubility.
– **Abstract: The addition of acid to a solution containing calcium phosphate will increase the solubility of the calcium phosphate. This is because as pH decreases, the dissolution rate increases and so does solubility. Another reason for this is that when an acid ionizes it becomes negatively charged which attracts positively charged ions in the solution. When these two charges collide they become neutralized and free to dissolve into each other more easily, thus increasing solubility.*
*This blog post has been compiled by Sam Rocha (srocha@engr). If you would like to contribute content or edits please email sam_roch@engr._edu_. Thank you!
* *References:
Ayers JE
